synergistic effect

Better fertilisation rate, embryo quality
and pregnancy rate


Number of patients
n = 100

(PROFERTIL® female group
n = 50; Control group n = 50)

Study design
Open single-center prospective randomized controlled pilot trial
Number of patients: 100

Clinical study to investigate the formulation of PROFERTIL® female
The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial

Study objectives
Primary objective of this pilot study was to determine the effect of PROfertil® female (compared to 400 mcg of folic acid) in women undergoing IVF in terms of embryo quality.
As a secondary objective of the study, the clinical pregnancy rate was evaluated.

Outcome parameters

  1. Embryo quality on day 3 after oocyte retrieval (good quality vs. poor quality) and
  2. Clinical pregnancy rate.

*Nouri K. et al., Gynecol Obstet Invest. 2017;82(1):8-14.