Treatment options

The chances of success are highly dependent on the personal conditions – such as the type of fertility disorder, how long the couple has been involuntarily childless and the ages of the woman and the man. Psychological aspects and the question of how many treatments the couple is prepared to undergo also play an important part in success.
The treatments are carried out in the form of a staged plan that depends on the individual problems of the couple who want to have a child.
PROfertil male and female can provide support at each of these stages of treatment and can bring about a “stage reduction”, among other benefits.

Semen analysis:

Since it is considerably simpler and faster to determine whether everything is alright with the quality of the man’s semen by means of a semen analysis, this test is recommended as the first step (semen analysis)

Cycle monitoring:

The goal is to accurately determine the time of ovulation and pinpoint the woman’s fertile period. The fertile days are closely monitored using ultrasound and hormone analysis and the doctor can determine the number, size and maturity of the follicles.
Meanwhile, PROfertil female helps the body to bring the cycle back into rhythm in a natural way and prepares it optimally for conception and pregnancy.

Drug therapy (hormone therapy):

Hormones can help bring the cycle back into rhythm but also stimulate the ovaries to produce egg cells. However, hormones generally have different side effects or may lead to hyperstimulation. You can find further information at

Methods of artificial insemination

Even with artificial insemination, the better the quality of the egg cell and the sperm, the higher the chances of success.
As has now been proven in 5 studies, PROfertil male improves the sperm quality with regard to all important parameters as well as improving the DNA integrity of the sperm. In this way, it can significantly contribute to increasing the chances of successful artificial insemination.
PROfertil female improves the embryo quality considerably, thus also increasing the chances of a successful pregnancy.

Artificially depositing semen in the uterus (insemination):

Insemination involves the doctor injecting purified, concentrated seminal fluid into the uterus, vagina, cervix or fallopian tubes. This method is considered if the quality of the sperm is slightly impaired or if the cervix is so scarred (due to infection or inflammation) that the sperm have difficulty reaching the uterus. It is sometimes necessary for the ovaries to be stimulated with hormones before insemination.

Fertilization of the egg cell outside of the body (IVF):

In this technique, the egg cell is fertilized outside of the body. IVF is considered if, for example, the egg cells do not reach the uterus because it is sticky as a result of inflammation. IVF can also help with a planned child if the woman has growths (myomas) in the uterus or antibodies against the sperm cells, or even if the doctor has found no cause for the infertility.

Injection of a sperm cell into the egg cell (ICSI):

With intracytoplasmic sperm injection (ICSI), the sperm is injected directly into the egg cell. ICSI is considered when the sperm cell cannot fertilize the egg cell either in the woman’s body or in a test tube and the woman fails to become pregnant despite IVF treatment. The so-called “male factor” is often the criterion for why ICSI eventually has to be used instead of IVF.

Microsurgical epididymal sperm aspiration/testicular sperm aspiration (MESA/TESA):

Sperm collection from the epididymis (microsurgical epididymal sperm aspiration, MESA) may help if the vasa deferentia are closed up and cannot be opened again with surgery or if the sperm in the semen sample are not moving. It is an option if the man cannot ejaculate, for example, because he is paraplegic or has had surgery for a tumor. If MESA cannot be carried out, some doctors recommend TESE (testicular sperm extraction), where the doctor extracts the sperm from the testicles. MESA and TESE are always combined with ICSI.